The Hazara Express was traveling from Karachi to Abbottabad, eight coaches have derailed," Mohsin Syal, a railway official said, NDTV reported.
At least 15 people were killed and more than 40 injured, Pakistan's state television channel reported, quoting railway officials.
The derailment happened near Sahara railway station in the city of Nawabshah in the southern Sindh province.
Ijaz Shah, a provincial railway official, told AFP that several passengers were killed and several others injured in the accident and that a relief train has been dispatched to the site.
Images posted to local media show dozens of people at the site, with some smashing windows to help passengers clamber out of the twisted carriages and at least one coach overturned.
SKH/PR
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