Human Rights Watch center described the explosions as very powerful and added that the cause of the blasts is not known yet.
Meanwhile, news sources added that several drones were flying over the same area when the explosions were heard.
An unidentified drone targeted the same US base with a barrage of missiles, sources familiar with the matter said on Saturday.
The US base was also targeted by several rockets last month. News sources called the attacks the "most severe" attack on the American base.
Al-Omar field is the largest oil field in Syria, where the American base is located in the east of Deir Ezzor. The Syrian government has repeatedly warned that the presence of US forces is illegal.
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