Iran-made nanosensor accurately measures nalbuphine in body

TEHRAN, Aug. 05 (MNA) – Iranian researchers succeeded in the synthesis of a nanocomposite sensor to precisely measure nalbuphine, a painkiller with major applications in heart attacks and preparation for surgery.

Nalbuphine is a semi-synthetic painkiller that has major applications in heart attacks and preparation for surgery and can be used as a tool during the general anesthesia after the operation. Similar to morphine, this drug is narcotic and is sometimes used by amphetamine addicts. According to Iran Nanotechnology Initiative Council (INIC), the aim of this research was to propose a simple method based on a sensor to detect and measure nalbuphine in real samples such as urine.

The sensor produced in this research is able to measure very tiny amounts of nalbuphine in biological samples. In addition, the application of this nanocomposite sensor prevents the side effects of the drug. The sensor also presents a simple and economic method for the measurement of nalbuphine.

In the first stage of the research, a nanocomposite of nickel oxide and functionalized carbon nanotubes was synthesized through nickel chemical deposition method in the presence of carbon nanotubes. The synthesized nanocomposite was used in the production of carbon paste electrode as well as ionic liquid, and electrochemical behavior of nalbuphine was studied on the surface of the electrode.

Test results showed that the produced sensor has a linear response in a wide range of nalbuphine concentration (0.2 to 500 µM). In addition, the sensor has a high selectivity for the desired drug.

Results of the research have been published in Sensors and Actuators B: Chemical, vol. 8, issue 320, 2016, pp. 456-462.


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