Heart failure increases concentration of hydrogen peroxide in the tissues, which damages inner lining of the artery, also called the endothelium, and raising the possibility of blood clot creation and heart and brain strokes. Thus, concentration of hydrogen peroxide in body fluids such as plasma gains importance. The mortality rate by cardiovascular diseases in the country has been in rise which makes necessary an easy, rapid, and efficient method of determining the hydrogen peroxide concentration to prevent any damage to heat and brain.
The research helped develop an electrochemical biosensor made of magnetic iron oxide nanoparticles and polyfouran which is capable of measuring hydrogen peroxide concentrations in biofluids and tissues. The research also removed minor disadvantages as lower conductivity and thermal stability of polyfuran.
Dr. Mehdi Baqayeri, Assistant Professor in Chemistry Department, Hakim Sabzevari University, told Mehr News that the component developed in the research would find other applications such as hydrogen peroxide concentrations in rain water for producing drink water, “since in some countries such as Australia, due to limited ground water reservoirs, they use rain water to meet part of their needs to drink water.”
“the component is a highly strong oxidation factor, reactions which produce free radicals and metals in troposphere; thus, the concentration of the hydrogen peroxide in rain water is an indication of toxicity, solubility, biocompatibility and relative amount of metallic elements in rain water,” explained he.
“The surface hydroxyl groups attached to iron oxide nanoparticles not only improve magnetic property and conductivity of the nanocomposite, but also they create better compatibility with furan rings to increase the surface-to-volume ratio necessary for biological applications,” Dr. Baqayeri added.
The materials used in nanocomposites are cheap, biocompatible, and could enter directly to body tissues. The research investigated some antioxidant properties of the nanocomposite and applications in biosensors for the first time in literature.
“A comparison of findings in this research with laboratory models indicated that using ultrasound waves in the nanocomposites improved conductivity, magnetic property, thermal stability, and antioxidant properties. These properties are directly related to minute size of the particles which would be improved through optimized conditions,” he said.
He added that the research group was currently working on developing a new generation of electrochemical biosensors to improve applied properties of the nanocomposites.
SH/HRGH
MNA
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