Nanosorbent detects tiny amounts of anticancer drugs in body

TEHRAN, Mar. 08 (MNA) – Iranian researchers from K. N. Toosi University of Technology produced a new nanosorbent to detect very low amount of anticancer drugs in biological samples, INIC reports.

Higher speed, lower cost and ease of access are among the important advantages of the nanosorbent to be used in laboratory diagnosis methods.

The production of appropriate sorbents with high efficiency and simple and cost-effective synthesis methods for the pre-concentration and extraction of drugs at very small amount (which is not directly measureable with other devices) from biological samples and the analysis of drugs by using devices will help the treatment of patients who suffer from cancer.

Therefore, metal-organic frameworks/polymer composite nanofibers were produced in this research through a very simple and cost-effective electrospinning method. Then, the performance of these nanofibers was investigated in the detection of very small amount of megestrol acetate and levonorgestrel though solid phase extraction method in biological samples.

According to Iran Nanotechnology Initiative Council (INIC), in this research, fibrous nanosorbents were synthesized by using metal-organic frameworks/polyacrylonitrile through electrospinning method. The nanosorbent can measure very small amounts of asteroid drugs in complex tissues without the need for advanced devices due to its high sorption capacity and high pre-concentration functions.

Test results showed that this method has a better performance in the detection of the drug in comparison with similar methods, and it requires less organic solvents and sorbents.

Results of the research have been published in Journal of Chromatography A, vol. 1426, 2015, pp. 24-32.




News Code 115080


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