Maryam Eslami, MD and PhD in Molecular Genetics of the Science and Research Branch carried out her dissertation in the Harvard University, told Mehr News science correspondent that with the ever-increasing cases of heart valve disorders, the probability of heart valve replacement rises dramatically; “with this in mind, researchers seek to find new methods to engineer tissues very identical to heart valve tissue,” she added.
“Using scaffolds in the structure of heart valve with effect on the secretion of the main components of the extracellular fluid such as Type I collagen and elastin gains significance; in this research, we conducted different biological, mechanical, and genetic experiments to examine the expression of collagen I and elastin in heart mitral valve cells cultured and encapsulated by microfiber hydrogel composite compared to those cultured and encapsulated by hydrogel and microfiber,” Eslami told Mehr News.
Eslami, who is a distinguished member of Elite Youth Research Club of the Science and Research Branch, added that cell survival and metabolic activity were identical in all scaffolds; “however, hydrogel significantly improved the 3D distribution of mitral valve interstitial cells,” she said. A summary of the research findings has been published in Biomaterials Applications and Cell specialist journals.
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