Ayatollah Khamenei addressed thousands of students on Sunday morning, a day before the 40th anniversary of the 1979 takeover of the US embassy in Tehran, which is marked every year with nationwide rallies.
The details of the meeting will be published later.
On November 4, 1979, a group of Iranian university students took over the US embassy in Tehran, which they believed had turned into a center of espionage aimed at overthrowing the Islamic Republic.
The day, which falls on the 13th day of the Iranian calendar month of Aban, is also known as the Student Day and the National Day of the Fight against Global Arrogance.
MNA/4761965