Homegrown nanosensor measures tiny amounts of Lysozyme

TEHRAN, Dec. 01 (MNA) – Iranian researchers designed a nano-biosensor with low detection limit that can accurately measure a type of an antibiotic protein in real samples.

According to Iran Nanotechnology Initiative Council (INIC), the protein studied in this research is antibacterial and the unusual amount of it in the body is a sign of disease.

Lysozyme is a protein found in tissues and secretions of mammals and in the egg white of bird eggs. The important role of lysozyme is its antibacterial properties. In fact, lysozyme is a natural antibiotic that helps the treatment of many diseases.

Unusual concentration of lysozyme in blood serum and urine can be a sign of diseases such as leukemia, kidney diseases and meningitis. Lysozyme also has larger applications in foodstuff and pharmaceutical industries due to its activity against bacteria cells, determined structure and low molecular weight. Therefore, it is important to measure lysozyme in the body. A nanobiosensor has been designed and produced based on gold nanoparticles in this research to measure lysozyme.

According to the evaluations, the sensor is able to accurately and quickly sense lysozyme protein in real and biological samples such as bird egg whites. This measurement is very important in foodstuff, pharmaceutical and therapeutic industries.

This measurement method is cost effective and does not require specific detectors. It can be easily used in the measurement of very small amounts of lysozyme. The design and production of the biosensor have been carried out in a way that the synthesized sample has very high sensitivity with very wide linear range and appropriate repeatability.

Results of the research have been published in Biosensors and Bioelectronics, vol. 74, 2015, pp. 270-276.




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