Head of Ilam International Airport, Mohammad Javad Yeganeh, said Tuesday that based on the agreement the direct route will start on October 9 and will run through October 25.
There will be four flights per day within the period, he added.
Arbaeen, which is one of the largest religious gatherings in the world, comes 40 days after Ashura, the martyrdom anniversary of the third Shia Imam, Imam Hussein (AS).
Each year, millions of Shias visit Karbala, where the holy shrine of Imam Hussein (AS) is located, to perform mourning rites.
This year, Arbaeen falls on Saturday, October 19.
Millions of people from around the world visit Karbala during Arbaeen.
With the facilitation of visa processes for Iranians and using more border crossings, some three million pilgrims are expected to take part in Arbaeen processions this year.
MNA/4710031