The accident occurred at 2:35 p.m. local time in the Barra Funda neighborhood in the western area of the city, the Fire Department said on its Twitter account.
The Fire Department, part of the Sao Paulo state Military Police, added that nine vehicles were affected by the crash and that it was "awaiting further information," Xinhua reported.
The helicopter, according to local media, was a Robinson R44 Raven II, apparently owned by an air taxi company.
Sao Paulo has 411 private registered helicopters, with 2,200 daily trips per 2021 data, according to the Brazilian Helicopter Pilots Association.
MP/PR