"We must keep in mind that one of the modifications of the F-16 can 'accommodate' nuclear weapons," Lavrov said in a speech at a military base in Dushanbe in Tajikistan, according to a transcript on the ministry's website, Reuters reported.
"If they do not understand this, then they are worthless as military strategists and planners."
Ukraine's President Volodymyr Zelenskiy has long appealed for the F-16 jets.
US President Joe Biden told G7 leaders last month that Washington supported joint allied training programs for Ukrainian pilots on F-16 fighters.
But US National Security adviser Jake Sullivan said there was no final decision on Washington sending aircraft.
AMK/PR