In Qazvin’s Sardar Azadegan Stadium, Rahman Jafari scored the winner just six minutes into the match.
It was Sepahan’s third consecutive loss after losing to Aluminum and Gol Gohar.
Esteghlal remain top of the 2023/24 Iran’s Persian Gulf Pro League (PGPL) tabbe with 32 points, followed by Sepahan (31) and Persepolis (30).