Fatemeh Lotfzadeh and Maryam Khalili were on target for Iran at the Dushanbe Central Stadium in Tajikistan.
The Persians had been held by Kyrgyzstan 1-1 in their opening match and edged past Uzbekistan 1-0.
The Central Asian Football Association (CAFA) is one of five regional bodies of governance in association football in Asia. It governs association football, futsal, and beach football in Central Asia.
CAFA consists of six national association members, namely Iran, Uzbekistan, Tajikistan, Kyrgyzstan, Afghanistan and Turkmenistan.
AMK/TT