Chrysin is a Bioflavonoids compound found in high levels in propolis and honey. It is used for bodybuilding, treating anxiety, inflammation, HIV/AIDS, and for preventing cancer.
Sina Mohammadinejad, one of the project researchers, said that cyclin D1 is a gene directly related to tumorigenesis; “in more than 50 percent of breast cancers, overexpression of this gene has been observed.”
“Chrysin plays an effective role in stopping the growth of cancer cells and reducing the expression of cyclin D1; for this reason, our study was conducted with the aim to investigate the effect of Chrysin in pure form and nanoencapsulated with Poly lactic-co-glycolic acid and Polyethylene glycol (PLGA-PEG) on T47D breast cancer cell line and cyclin D1 gene expression,” explained Mohammadinejad.
“There is potential for use of these nanoparticles for biomedical applications. Future work should include in vivo investigation of the targeting capability and effectiveness of these nanoparticles in the treatment of breast cancer,” he said.
Mohammadinejad added that the project is still in its initial phase and the studies have been so far conducted on one cancer cell line and gene. He maintained that further studies were needed in order to use the results of the research to produce the desired nano-medicine in treating breast cancer.
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