The accident occurred late on Wednesday officials say, when the vehicle lost control before falling into a ravine.
More than 40 are also being treated for injuries in Karachi and police have warned casualties could rise, BBC reported.
High fatality crashes are common in Pakistan, often caused by driver error and poorly-maintained roads.
Balochistan Chief Minister Sindh Murad Ali Shah told reporters that two children were among the injured, and that at least five people had sustained serious head injuries.
He added that the details of the accident were still under investigation.
MP/PR