Both opened their campaigns with resounding wins on Thursday while Hong Kong and Turkmenistan will square off needing the points.
Iran, seeking to qualify for a fourth consecutive FIFA World Cup, was in a class of its own against Hong Kong at the Azadi Stadium on Matchday One.
Sardar Azmoun led the way with a brace as Iran staked an early claim on a spot in the next round.
Uzbekistan was equally impressive, defeating Central Asian rival Turkmenistan away as it started its campaign to make the third round after missing out on the same stage for the 2022 edition.
SD/TSN