"In the Limites sector, on the national highway of the municipality of Playon, an accident occurred involving a bus of the Brasilia company, which left 10 people dead," the agency said on Twitter on Saturday.
The 30 people injured in the accident have been taken to local hospitals.
The cause of the accident is under investigation.
Caracol radio reported on Saturday that the bus was carrying South American migrants who were heading to the north of the country to later attempt to reach the United States.
RHM/PR