The collision happened near Ngeun Sarr in the country's north, President Macky Sall tweeted, according to Associated Press.
“Yet another fatal accident on our roads," he said. “My heartfelt condolences to the bereaved families. Speedy recovery to the injured."
The crash involved a public bus and a transport truck, the fire department said. The bus was apparently trying to avoid hitting a donkey, local fire department commander Lt. Ousseynou Ndiaye said.
Last week, 40 people were killed in a bus crash in Gnivy village, in Senegal's Kaffrine region. After that crash, the government announced reforms to try and stem collisions.
Traffic crashes happen regularly in the West African nation because of poor roads, bad cars and drivers not adhering to the rules, locals say.
In 2017, at least 25 people were killed when two buses also crashed. Many of those people were heading toward the central town of Touba for the annual Muslim pilgrimage.
MNA/PR