Although scientists have been able to culture cells outside the body for years, the technology to grow complicated and three-dimensional networks have recently been developed to be replaced with the damaged tissue.
According to the definition, a scaffold should be designed with appropriate physical properties with the ability for the cells to stick to it, cellular migration, proliferation and distinguish to produce a tissue through engineering methods.
According to Iran Nanotechnology Initiative Council (INIC), the aim of this research was to produce a three-dimensional scaffold with appropriate microstructure and biological properties by using polymeric nanofibers in a way that the produced scaffold has higher efficiency and biocompatibility than similar products.
Nanofibers have been designed in this research in a three-dimensional manner. This fact significantly increases electrical conductivity of the scaffold, to the extent that they present much higher cellular migration in comparison with the two-dimensional product. Modified electrospinning process was first designed in this research. Then, optimum conditions were determined for the synthesis of three-dimensional nanofibers. The scaffold was produced next by using polyaniline/polycaprolactone solution. Finally, the produced structure was investigated from structural and biological points of view.
Observations showed that when the concentration of polyaniline reaches 70% from 7%, fibers convert from two-dimensional phase to three-dimensional, and electrical conductivity increases 1,000 times.
MS/PR