Nanodrug helps treat breast cancer

News ID: 3039697 -
TEHRAN, Feb. 02 (MNA) – Researchers in Islamic Azad University have developed a bioadaptive polymers modified with iron nanoparticles which would help treat breast cancer with the least damage to unaffected tissues.

Changes in modern lifestyle, environmental pollutions, unhealthy food choices and a host of other factors have raised cancer as the major player among incurable diseases. The cancer have provoked different responses as different treatments with chemotherapy as the main strand. However, the strand has huge side-effects evident in hair loss, skin lesions, etc. which adversely affects the physical as well as mental disposition of the patients.

Hamid Hashemi Moghaddam told Mehr News science correspondent on Monday that the difficulties in treating cancer have given way to diverse methods of drug delivery to target tissues and of preventing side-effects in unaffected tissues,” he said.

“Targeted delivery however, incurs huge expenses, increases cytotoxicity, and in some cases, it decreases the efficacy of the medication which is a serious barrier to commercial applications of the drug; the present research has synthetized a highly applied nanoparticle which is cheap, environment-friendly, and bioadaptive, in composition of an anti-cancer drug delivery system,” said the researcher, “tests on mice with breast cancer indicate high percentage of success. Measuring of drug amounts in other tissues reveals sediments of tiny and negligible amounts, but high concentrations in target malignant tumor.”

“The mechanism minimizes the adverse side-effects of the drug on unaffected cells; “the process makes possible the least cytotoxicity; the NP drug is a polymer matrix modified with a core of magnetic iron nanoparticles, and its structure has been verified by FTIR spectroscopy, and surface features has been evaluated by SEM (Scanning Electron Microscopy),” he told Mehr News.

“The research examined the NP delivery system effects on slowing tumor growth and the histopathology of the tumor; drug dispersal in healthy cells of mice was measured through HPLC method and atomic absorption; the base polymer is poly-dopamine modified with iron nanoparticles. This is a very bioadaptive and cheaply produced and has negligible toxicity,” Hashemi Moghaddam said. “Nano scale provides better permeability for tissues; we predict using the magnetic clothing in the texture of special clothing which would help better concentrations of drug in target tissues,” he concluded.

 

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